p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet.
BACKGROUND:p8 was initially described as being overexpressed in acute pancreatitis and encoding a ubiquitous stress protein.Analysis of insulin sensitivity and glucose tolerance in p8-knockout and haplodeficient mice revealed counterintuitive results.Thus, we determined glycemic control of p8 in mice fed with standard (SD) and high-fat diet Hasbro